Esterase-activated release of naproxen from supramolecular nanofibres.
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ABSTRACT:
SUBMITTER: Conda-Sheridan M
PROVIDER: S-EPMC4201510 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
Esterase-activated release of naproxen from supramolecular nanofibres.
Conda-Sheridan Martin M Lee Sungsoo S SS Preslar Adam T AT Stupp Samuel I SI
Chemical communications (Cambridge, England) 20141101 89
Nanofibre forming peptide amphiphiles were conjugated to naproxen through an esterase-sensitive linker. The amount of naproxen released, in the presence of enzymes, was influenced by the linker conjugating the drug to the supramolecular assembly. In vitro studies showed the anti-inflammatory activity of the released drug was maintained. ...[more]
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