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Negative reinforcement impairs overnight memory consolidation.

ABSTRACT: Post-learning sleep is beneficial for human memory. However, it may be that not all memories benefit equally from sleep. Here, we manipulated a spatial learning task using monetary reward and performance feedback, asking whether enhancing the salience of the task would augment overnight memory consolidation and alter its incorporation into dreaming. Contrary to our hypothesis, we found that the addition of reward impaired overnight consolidation of spatial memory. Our findings seemingly contradict prior reports that enhancing the reward value of learned information augments sleep-dependent memory processing. Given that the reward followed a negative reinforcement paradigm, consolidation may have been impaired via a stress-related mechanism.

SUBMITTER: Stamm AW

PROVIDER: S-EPMC4201816 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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Negative reinforcement impairs overnight memory consolidation.

Stamm Andrew W AW Nguyen Nam D ND Seicol Benjamin J BJ Fagan Abigail A Oh Angela A Drumm Michael M Lundt Maureen M Stickgold Robert R Wamsley Erin J EJ

Learning & memory (Cold Spring Harbor, N.Y.) 20141015 11

Post-learning sleep is beneficial for human memory. However, it may be that not all memories benefit equally from sleep. Here, we manipulated a spatial learning task using monetary reward and performance feedback, asking whether enhancing the salience of the task would augment overnight memory consolidation and alter its incorporation into dreaming. Contrary to our hypothesis, we found that the addition of reward impaired overnight consolidation of spatial memory. Our findings seemingly contradi ...[more]

PMID: 25320351

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