Ontology highlight
ABSTRACT:
SUBMITTER: Gault J
PROVIDER: S-EPMC4201860 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Gault Joseph J Malosse Christian C Machata Silke S Millien Corinne C Podglajen Isabelle I Ploy Marie-Cécile MC Costello Catherine E CE Duménil Guillaume G Chamot-Rooke Julia J
Proteomics 20140312 10
In pathogenic bacteria, posttranslationally modified proteins have been found to promote bacterial survival, replication, and evasion from the host immune system. In the human pathogen Neisseria meningitidis, the protein PilE (15-18 kDa) is the major building block of type IV pili, extracellular filamentous organelles that play a major role in mediating pathogenesis. Previous reports have shown that PilE can be expressed as a number of different proteoforms, each harboring its own set of PTMs an ...[more]