Ontology highlight
ABSTRACT:
SUBMITTER: Ranjan R
PROVIDER: S-EPMC4201910 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Ranjan Ravi R Deng Jing J Chung Sangwoon S Lee Yong Gyu YG Park Gye Young GY Xiao Lei L Joo Myungsoo M Christman John William JW Karpurapu Manjula M
Journal of innate immunity 20140620 6
The role of the transcription factor nuclear factor of activated T cells (NFAT) was initially identified in T and B cell gene expression, but its role in regulating gene expression in macrophages during sepsis is not known. Our data show that NFATc3 regulates expression of inducible nitric oxide synthase (iNOS) in macrophages stimulated with lipopolysaccharide. Selective inhibition of NFAT by cyclosporine A and a competitive peptide inhibitor 11R-VIVIT inhibited endotoxin-induced expression of i ...[more]