Ontology highlight
ABSTRACT:
SUBMITTER: Pinto L
PROVIDER: S-EPMC4201942 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Pinto Lucas L Goard Michael J MJ Estandian Daniel D Xu Min M Kwan Alex C AC Lee Seung-Hee SH Harrison Thomas C TC Feng Guoping G Dan Yang Y
Nature neuroscience 20131027 12
The basal forebrain provides the primary source of cholinergic input to the cortex, and it has a crucial function in promoting wakefulness and arousal. However, whether rapid changes in basal forebrain neuron spiking in awake animals can dynamically influence sensory perception is unclear. Here we show that basal forebrain cholinergic neurons rapidly regulate cortical activity and visual perception in awake, behaving mice. Optogenetic activation of the cholinergic neurons or their V1 axon termin ...[more]