Ontology highlight
ABSTRACT:
SUBMITTER: Chen ZH
PROVIDER: S-EPMC4201947 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Cell reports 20140904 6
Chromatin organization and dynamics are integral to global gene transcription. Histone modification influences chromatin status and gene expression. PTEN plays multiple roles in tumor suppression, development, and metabolism. Here, we report on the interplay of PTEN, histone H1, and chromatin. We show that loss of PTEN leads to dissociation of histone H1 from chromatin and decondensation of chromatin. PTEN deletion also results in elevation of histone H4 acetylation at lysine 16, an epigenetic m ...[more]