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Human CD141+ dendritic cells induce CD4+ T cells to produce type 2 cytokines.

ABSTRACT: Dendritic cells (DCs) play the central role in the priming of naive T cells and the differentiation of unique effector T cells. In this study, using lung tissues and blood from both humans and humanized mice, we analyzed the response of human CD1c(+) and CD141(+) DC subsets to live-attenuated influenza virus. Specifically, we analyzed the type of CD4(+) T cell immunity elicited by live-attenuated influenza virus-exposed DCs. Both DC subsets induce proliferation of allogeneic naive CD4(+) T cells with the capacity to secrete IFN-?. However, CD141(+) DCs are uniquely able to induce the differentiation of IL-4- and IL-13-producing CD4(+) T cells. CD141(+) DCs induce IL-4- and IL-13-secreting CD4(+) T cells through OX40 ligand. Thus, CD141(+) DCs demonstrate remarkable plasticity in guiding adaptive immune responses.

SUBMITTER: Yu CI

PROVIDER: S-EPMC4201960 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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Human CD141+ dendritic cells induce CD4+ T cells to produce type 2 cytokines.

Yu Chun I CI Becker Christian C Metang Patrick P Marches Florentina F Wang Yuanyuan Y Toshiyuki Hori H Banchereau Jacques J Merad Miriam M Palucka A Karolina AK

Journal of immunology (Baltimore, Md. : 1950) 20140922 9

Dendritic cells (DCs) play the central role in the priming of naive T cells and the differentiation of unique effector T cells. In this study, using lung tissues and blood from both humans and humanized mice, we analyzed the response of human CD1c(+) and CD141(+) DC subsets to live-attenuated influenza virus. Specifically, we analyzed the type of CD4(+) T cell immunity elicited by live-attenuated influenza virus-exposed DCs. Both DC subsets induce proliferation of allogeneic naive CD4(+) T cells ...[more]

PMID: 25246496

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Functional Human CD141+ Dendritic Cells in Human Immune System Mice.

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Circulating precursors of human CD1c+ and CD141+ dendritic cells.

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Retinoic acid treated human dendritic cells induce T regulatory cells via the expression of CD141 and GARP which is impaired with age.

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Coexpression of CD163 and CD141 identifies human circulating IL-10-producing dendritic cells (DC-10).

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| S-EPMC6103814 | biostudies-literature

Human CD4 T-Cells With a Naive Phenotype Produce Multiple Cytokines During Mycobacterium Tuberculosis Infection and Correlate With Active Disease.

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