Ontology highlight
ABSTRACT:
SUBMITTER: Mukherjee N
PROVIDER: S-EPMC4202108 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Mukherjee Nobina N Jose Mac Donald MD Birkner Jan Peter JP Walko Martin M Ingólfsson Helgi I HI Dimitrova Anna A Arnarez Clément C Marrink Siewert J SJ Koçer Armağan A
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20140623 10
One of the best-studied mechanosensitive channels is the mechanosensitive channel of large conductance (MscL). MscL senses tension in the membrane evoked by an osmotic down shock and directly couples it to large conformational changes leading to the opening of the channel. Spectroscopic techniques offer unique possibilities to monitor these conformational changes if it were possible to generate tension in the lipid bilayer, the native environment of MscL, during the measurements. To this end, as ...[more]