Ontology highlight
ABSTRACT:
SUBMITTER: Caratozzolo MF
PROVIDER: S-EPMC4202135 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Caratozzolo Mariano Francesco MF Valletti Alessio A Gigante Margherita M Aiello Italia I Mastropasqua Francesca F Marzano Flaviana F Ditonno Pasquale P Carrieri Giuseppe G Simonnet Hélène H D'Erchia Anna Maria AM Ranieri Elena E Pesole Graziano G Sbisà Elisabetta E Tullo Apollonia A
Oncotarget 20140901 17
In some tumours, despite a wild-type p53 gene, the p53 pathway is inactivated by alterations in its regulators or by unknown mechanisms, leading to resistance to cytotoxic therapies. Understanding the mechanisms of functional inactivation of wild-type p53 in these tumours may help to define prospective targets for treating cancer by restoring p53 activity. Recently, we identified TRIM8 as a new p53 modulator, which stabilizes p53 impairing its association with MDM2 and inducing the reduction of ...[more]