Ontology highlight
ABSTRACT:
SUBMITTER: Andrukhova O
PROVIDER: S-EPMC4203353 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Andrukhova Olena O Slavic Svetlana S Smorodchenko Alina A Zeitz Ute U Shalhoub Victoria V Lanske Beate B Pohl Elena E EE Erben Reinhold G RG
EMBO molecular medicine 20140406 6
Fibroblast growth factor-23 (FGF23) is a bone-derived hormone regulating renal phosphate reabsorption and vitamin D synthesis in renal proximal tubules. Here, we show that FGF23 directly regulates the membrane abundance of the Na(+):Cl(-) co-transporter NCC in distal renal tubules by a signaling mechanism involving the FGF receptor/αKlotho complex, extracellular signal-regulated kinase 1/2 (ERK1/2), serum/glucocorticoid-regulated kinase 1 (SGK1), and with-no lysine kinase-4 (WNK4). Renal sodium ...[more]