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A chemoselective route to ?-enamino esters and thioesters.

ABSTRACT: Conditions were developed for syntheses of ?-enamino esters, thioesters, and amides. These reactions involve hydroxybenzotriazole derivatives in buffered media. Illustrative syntheses of some heterocyclic systems are given, including some related to protein-protein interface mimics.

SUBMITTER: Xin D

PROVIDER: S-EPMC4203388 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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A chemoselective route to β-enamino esters and thioesters.

Xin Dongyue D Burgess Kevin K

Organic letters 20140331 8

Conditions were developed for syntheses of β-enamino esters, thioesters, and amides. These reactions involve hydroxybenzotriazole derivatives in buffered media. Illustrative syntheses of some heterocyclic systems are given, including some related to protein-protein interface mimics. ...[more]

PMID: 24679218

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