Ontology highlight
ABSTRACT:
SUBMITTER: Chen W
PROVIDER: S-EPMC4203552 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Chen Wei W Zhang Lisheng L Zhang Keqiang K Zhou Bingsen B Kuo Mei-Ling ML Hu Shuya S Chen Linling L Tang Michelle M Chen Yun-Ru YR Yang Lixin L Ann David K DK Yen Yun Y
Autophagy 20140516 7
Ribonucleotide reductase (RNR) plays a critical role in catalyzing the biosynthesis and maintaining the intracellular concentration of 4 deoxyribonucleoside triphosphates (dNTPs). Unbalanced or deficient dNTP pools cause serious genotoxic consequences. Autophagy is the process by which cytoplasmic constituents are degraded in lysosomes to maintain cellular homeostasis and bioenergetics. However, the role of autophagy in regulating dNTP pools is not well understood. Herein, we reported that starv ...[more]