Ontology highlight
ABSTRACT:
SUBMITTER: Pei Q
PROVIDER: S-EPMC4203722 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Pei Qi Q Wang Yan Y Hu Zhe-Yi ZY Liu Shi-Kun SK Tan Hong-Yi HY Guo Cheng-Xian CX Zhang Ran-Ran RR Xiang Yu-Xia YX Huang Jie J Huang Lu L Yuan Hong H Yang Guo-Ping GP
PloS one 20141020 10
<h4>Objectives</h4>We aim to obtain the intra-subject coefficient of variability of a highly variable antidepressant agomelatine in humans, and propose an adjusted bioequivalence assessment strategy.<h4>Methods</h4>A single-dose, randomized crossover design was conducted in four periods (reference administered thrice, placebo administered once) separated by seven days. A validated LC-MS/MS assay was used to measure drug concentrations in serial blood samples.<h4>Results</h4>The intra-subject coe ...[more]