Ontology highlight
ABSTRACT:
SUBMITTER: Lu D
PROVIDER: S-EPMC4203942 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20141006 11
A single microRNA (miRNA) can regulate the expression of many genes, though the level of repression imparted on any given target is generally low. How then is the selective pressure for a single miRNA/target interaction maintained across long evolutionary distances? We addressed this problem by disrupting in vivo the interaction between miR-155 and PU.1 in mice. Remarkably, this interaction proved to be key to promoting optimal T cell-dependent B cell responses, a previously unrecognized role fo ...[more]