Ontology highlight
ABSTRACT:
SUBMITTER: Wu B
PROVIDER: S-EPMC420397 | biostudies-literature | 2004 Jun
REPOSITORIES: biostudies-literature
Wu Beili B Li Pengyun P Liu Yiwei Y Lou Zhiyong Z Ding Yi Y Shu Cuiling C Ye Sheng S Bartlam Mark M Shen Beifen B Rao Zihe Z
Proceedings of the National Academy of Sciences of the United States of America 20040524 22
FK506-binding protein 52 (FKBP52), which binds FK506 and possesses peptidylprolyl isomerase activity, is an important immunophilin involved in the heterocomplex of steroid receptors with heat-shock protein 90. Here we report the crystal structures of two overlapped fragments [N(1-260) and C(145-459)] of FKBP52 and the complex with a C-terminal pentapeptide from heat-shock protein 90. Based on the structures of these two overlapped fragments, the complete putative structure of FKBP52 can be defin ...[more]