Ontology highlight
ABSTRACT:
SUBMITTER: Robert S
PROVIDER: S-EPMC4204023 | biostudies-literature | 2013 Mar-Apr
REPOSITORIES: biostudies-literature
Islets 20130301 2
In type 1 diabetic patients insulin-producing pancreatic β-cells are destroyed by an orchestrated immune process involving self-reactive auto-antigen-specific CD4⁺ and CD8⁺ T cells. Efforts to reverse or prevent this destructive immunological cascade have led to promising results in animal models, however, the transition to the clinic has yet been unsuccessful. In addition, current clinical studies lack reliable biomarkers to circumscribe end-point parameters and define therapeutic success. Here ...[more]