Computational prediction of candidate proteins for S-nitrosylation in Arabidopsis thaliana.

ABSTRACT: Nitric oxide (NO) is an important signaling molecule that regulates many physiological processes in plants. One of the most important regulatory mechanisms of NO is S-nitrosylation-the covalent attachment of NO to cysteine residues. Although the involvement of cysteine S-nitrosylation in the regulation of protein functions is well established, its substrate specificity remains unknown. Identification of candidates for S-nitrosylation and their target cysteine residues is fundamental for studying the molecular mechanisms and regulatory roles of S-nitrosylation in plants. Several experimental methods that are based on the biotin switch have been developed to identify target proteins for S-nitrosylation. However, these methods have their limits. Thus, computational methods are attracting cons

SUBMITTER: Chaki M 

PROVIDER: S-EPMC4204854 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature