Ontology highlight
ABSTRACT:
SUBMITTER: Nakagawa A
PROVIDER: S-EPMC4205001 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Nakagawa Akito A Lui Francine E FE Wassaf Dina D Yefidoff-Freedman Revital R Casalena Dominick D Palmer Michelle A MA Meadows Jacqueline J Mozzarelli Andrea A Ronda Luca L Abdulmalik Osheiza O Bloch Kenneth D KD Safo Martin K MK Zapol Warren M WM
ACS chemical biology 20140811 10
Small molecules that increase the oxygen affinity of human hemoglobin may reduce sickling of red blood cells in patients with sickle cell disease. We screened 38,700 compounds using small molecule microarrays and identified 427 molecules that bind to hemoglobin. We developed a high-throughput assay for evaluating the ability of the 427 small molecules to modulate the oxygen affinity of hemoglobin. We identified a novel allosteric effector of hemoglobin, di(5-(2,3-dihydro-1,4-benzodioxin-2-yl)-4H ...[more]