Ontology highlight
ABSTRACT:
SUBMITTER: Hongo D
PROVIDER: S-EPMC4205183 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Hongo D D Tang X X Baker J J Engleman E G EG Strober S S
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20141013 11
The goal of the study was to elucidate the cellular and molecular mechanisms by which a clinically applicable immune tolerance regimen of combined bone marrow and heart transplants in mice results in mixed chimerism and graft acceptance. The conditioning regimen of lymphoid irradiation and anti-T cell antibodies changed the balance of cells in the lymphoid tissues to create a tolerogenic microenvironment favoring the increase of natural killer T (NKT) cells, CD4+ CD25+ regulatory T cells and Gr- ...[more]