Ontology highlight
ABSTRACT:
SUBMITTER: Sampath D
PROVIDER: S-EPMC4205589 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Leukemia research 20130806 11
Akt, a serine/threonine protein kinase, is constitutively phosphorylated and hyperactivated in multiple cancers, including acute myeloid leukemia. High levels are linked to poor survival and inferior responses to chemotherapy, making Akt inhibition an attractive therapeutic target. In this phase I/II study of TCN-PM, a small-molecule Akt inhibitor, TCN-PM therapy was well tolerated in patients with advanced hematological malignancies, and reduced levels of phosphorylation of Akt and its substrat ...[more]