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ABSTRACT: Objective
To review the current evidence and make practice recommendations regarding the diagnosis and treatment of limb-girdle muscular dystrophies (LGMDs).Methods
Systematic review and practice recommendation development using the American Academy of Neurology guideline development process.Results
Most LGMDs are rare, with estimated prevalences ranging from 0.07 per 100,000 to 0.43 per 100,000. The frequency of some muscular dystrophies varies based on the ethnic background of the population studied. Some LGMD subtypes have distinguishing features, including pattern of muscle involvement, cardiac abnormalities, extramuscular involvement, and muscle biopsy findings. The few published therapeutic trials were not designed to establish clinical efficacy of any treatment.Principal recommendations
For patients with suspected muscular dystrophy, clinicians should use a clinical approach to guide genetic diagnosis based on clinical phenotype, inheritance pattern, and associated manifestations (Level B). Clinicians should refer newly diagnosed patients with an LGMD subtype and high risk of cardiac complications for cardiology evaluation even if they are asymptomatic from a cardiac standpoint (Level B). In patients with LGMD with a known high risk of respiratory failure, clinicians should obtain periodic pulmonary function testing (Level B). Clinicians should refer patients with muscular dystrophy to a clinic that has access to multiple specialties designed specifically to care for patients with neuromuscular disorders (Level B). Clinicians should not offer patients with LGMD gene therapy, myoblast transplantation, neutralizing antibody to myostatin, or growth hormone outside of a research study designed to determine efficacy and safety of the treatment (Level R). Detailed results and recommendations are available on the Neurology® Web site at Neurology.org.
SUBMITTER: Narayanaswami P
PROVIDER: S-EPMC4206155 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Narayanaswami Pushpa P Weiss Michael M Selcen Duygu D David William W Raynor Elizabeth E Carter Gregory G Wicklund Matthew M Barohn Richard J RJ Ensrud Erik E Griggs Robert C RC Gronseth Gary G Amato Anthony A AA
Neurology 20141001 16
<h4>Objective</h4>To review the current evidence and make practice recommendations regarding the diagnosis and treatment of limb-girdle muscular dystrophies (LGMDs).<h4>Methods</h4>Systematic review and practice recommendation development using the American Academy of Neurology guideline development process.<h4>Results</h4>Most LGMDs are rare, with estimated prevalences ranging from 0.07 per 100,000 to 0.43 per 100,000. The frequency of some muscular dystrophies varies based on the ethnic backgr ...[more]