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Rhodium(III)-Catalyzed C-H Activation Mediated Synthesis of Isoquinolones from Amides and Cyclopropenes.

ABSTRACT: We have developed a synthesis of 4-substituted isoquinolones from the Rh(III)-catalyzed, C-H activation mediated, coupling of O-pivaloyl benzhydroxamic acids and 3,3-disubstituted cyclopropenes. Experiments suggest the formation of a [4.1.0] bicyclic-system, which can open under acidic conditions to generate the desired isoquinolone.

SUBMITTER: Hyster TK

PROVIDER: S-EPMC4206942 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Rhodium(III)-Catalyzed C-H Activation Mediated Synthesis of Isoquinolones from Amides and Cyclopropenes.

Hyster Todd K TK Rovis Tomislav T

Synlett : accounts and rapid communications in synthetic organic chemistry 20130101 14

We have developed a synthesis of 4-substituted isoquinolones from the Rh(III)-catalyzed, C-H activation mediated, coupling of <i>O</i>-pivaloyl benzhydroxamic acids and 3,3-disubstituted cyclopropenes. Experiments suggest the formation of a [4.1.0] bicyclic-system, which can open under acidic conditions to generate the desired isoquinolone. ...[more]

PMID: 25346576

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