Correlates of polysomnographic sleep changes in cocaine dependence: self-administration and clinical outcomes.

ABSTRACT:

Background

Abstinence from chronic cocaine use is associated with abnormal sleep architecture. As sleep abnormalities are associated with clinical outcome in alcohol dependence, we hypothesized a similar relationship in cocaine dependence.

Methods

We report data from a cocaine self-administration study (N=12) and the placebo arm of a randomized clinical trial (N=20). Self-administration participants underwent three cocaine self-administration sessions during a three-week inpatient stay. Treatment participants underwent two weeks of inpatient followed by six weeks of outpatient treatment including once-weekly cognitive behavioral therapy. Measurements included polysomnography from early and late in abstinence during the inpatient stays. Clinical outcomes included amount of co

SUBMITTER: Angarita GA 

PROVIDER: S-EPMC4207081 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature