Ontology highlight
ABSTRACT:
SUBMITTER: Mesirca P
PROVIDER: S-EPMC4207211 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Mesirca Pietro P Alig Jacqueline J Torrente Angelo G AG Müller Jana Christina JC Marger Laurine L Rollin Anne A Marquilly Claire C Vincent Anne A Dubel Stefan S Bidaud Isabelle I Fernandez Anne A Seniuk Anika A Engeland Birgit B Singh Jasmin J Miquerol Lucile L Ehmke Heimo H Eschenhagen Thomas T Nargeot Joel J Wickman Kevin K Isbrandt Dirk D Mangoni Matteo E ME
Nature communications 20140821
The mechanisms underlying cardiac automaticity are still incompletely understood and controversial. Here we report the complete conditional and time-controlled silencing of the 'funny' current (If) by expression of a dominant-negative, non-conductive HCN4-channel subunit (hHCN4-AYA). Heart-specific If silencing caused altered [Ca(2+)]i release and Ca(2+) handling in the sinoatrial node, impaired pacemaker activity and symptoms reminiscent of severe human disease of pacemaking. The effects of If ...[more]