Ontology highlight
ABSTRACT:
SUBMITTER: Doiron JA
PROVIDER: S-EPMC4207410 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Doiron Jérémie A JA Métayer Benoît B Richard Ryan R RR Desjardins Dany D Boudreau Luc H LH Levesque Natalie A NA Jean-François Jacques J Poirier Samuel J SJ Surette Marc E ME Touaibia Mohamed M
International journal of medicinal chemistry 20140218
5-Lipoxygenase (5-LO) is the key enzyme responsible for the conversion of arachidonic acid to leukotrienes, a class of lipid mediators implicated in inflammatory disorders. In this paper, we describe the design, synthesis, and preliminary activity studies of novel clicked caffeic esters and amides as radical scavengers and 5-LO inhibitors. From known 5-LO inhibitor 3 as a lead, cinnamic esters 8a-h and amides 9a-h as well as caffeic esters 15a-h and amides 16a-h were synthesized by Cu(I)-catalyz ...[more]