Ontology highlight
ABSTRACT:
SUBMITTER: Kim JE
PROVIDER: S-EPMC4207472 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Kim J-E JE Ryu H J HJ Kim M J MJ Kang T-C TC
Cell death and differentiation 20140221 7
Although the aberrant activation of cell cycle proteins has a critical role in neuronal death, effectors or mediators of cyclin D1/cyclin-dependent kinase 4 (CDK4)-mediated death signal are still unknown. Here, we describe a previously unsuspected role of LIM kinase 2 (LIMK2) in programmed necrotic neuronal death. Downregulation of p27(Kip1) expression by Rho kinase (ROCK) activation induced cyclin D1/CDK4 expression levels in neurons vulnerable to status epilepticus (SE). Cyclin D1/CDK4 complex ...[more]