Ontology highlight
ABSTRACT:
SUBMITTER: Phillips O
PROVIDER: S-EPMC4207674 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Phillips Owen O Squitieri Ferdinando F Sanchez-Castaneda Cristina C Elifani Francesca F Caltagirone Carlo C Sabatini Umberto U Di Paola Margherita M
PloS one 20141023 10
White matter (WM) abnormalities have already been shown in presymptomatic (Pre-HD) and symptomatic HD subjects using Magnetic Resonance Imaging (MRI). In the present study, we examined the microstructure of the long-range large deep WM tracts by applying two different MRI approaches: Diffusion Tensor Imaging (DTI) -based tractography, and T2*weighted (iron sensitive) imaging. We collected Pre-HD subjects (n = 25), HD patients (n = 25) and healthy control subjects (n = 50). Results revealed incre ...[more]