Ontology highlight
ABSTRACT:
SUBMITTER: Xiang Z
PROVIDER: S-EPMC4207808 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Xiang Zheng Z Wang Sen S Xiang Yao Y
PloS one 20141023 10
Emerging evidence showed miR499a could not only function as an oncogene but also as a tumor suppressor in various types of cancer, such as melanoma. However, whether miR499a was involved in hepatocarcinogenesis remains unknown. We previously reported that miR499a was up-regulated in HBV-mediated hepatocellular carcinoma (HCC). In this study, we found that HBV could induce the expression of miR499a by promoting its promoter activity. In addition, we reported that miR499a increased cell proliferat ...[more]