Ontology highlight
ABSTRACT:
SUBMITTER: Samba-Louaka A
PROVIDER: S-EPMC4207825 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Samba-Louaka Ascel A Pereira Jorge M JM Nahori Marie-Anne MA Villiers Veronique V Deriano Ludovic L Hamon Mélanie A MA Cossart Pascale P
PLoS pathogens 20141023 10
The DNA damage response (DDR) is an essential signaling pathway that detects DNA lesions, which constantly occur upon either endogenous or exogenous assaults, and maintains genetic integrity. An infection by an invading pathogen is one such assault, but how bacteria impact the cellular DDR is poorly documented. Here, we report that infection with Listeria monocytogenes induces host DNA breaks. Strikingly, the signature response to these breaks is only moderately activated. We uncover the role of ...[more]