Ontology highlight
ABSTRACT:
SUBMITTER: Cole F
PROVIDER: S-EPMC4207963 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Cole Francesca F Baudat Frédéric F Grey Corinne C Keeney Scott S de Massy Bernard B Jasin Maria M
Nature genetics 20140824 10
The ability to examine all chromatids from a single meiosis in yeast tetrads has been indispensable for defining the mechanisms of homologous recombination initiated by DNA double-strand breaks (DSBs). Using a broadly applicable strategy for the analysis of chromatids from a single meiosis at two recombination hotspots in mouse oocytes and spermatocytes, we demonstrate here the unidirectional transfer of information-gene conversion-in both crossovers and noncrossovers. Whereas gene conversion in ...[more]