Ontology highlight
ABSTRACT:
SUBMITTER: Konradi C
PROVIDER: S-EPMC4208672 | biostudies-literature | 2004 Nov
REPOSITORIES: biostudies-literature
Konradi Christine C Westin Jenny E JE Carta Manolo M Eaton Molly E ME Kuter Katarzyna K Dekundy Andrzej A Lundblad Martin M Cenci M Angela MA
Neurobiology of disease 20041101 2
We have examined the pattern of striatal messenger RNA expression of over 8000 genes in a rat model of levodopa (L-DOPA)-induced dyskinesia and Parkinson disease (PD). 6-Hydroxydopamine (6-OHDA)-lesioned rats were treated with L-DOPA or physiological saline for 22 days and repeatedly tested for antiakinetic response to L-DOPA and the development of abnormal involuntary movements (AIMs). In a comparison of rats that developed a dyskinetic motor response to rats that did not, we found striking dif ...[more]