Ontology highlight
ABSTRACT:
SUBMITTER: Wacker I
PROVIDER: S-EPMC4208853 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Wacker Ingrid I Behrens Jürgen J
PloS one 20141024 10
Activin B belongs to the TGFβ family of growth factors and is upregulated in clear cell renal cell carcinoma cells by hypoxia inducible factors. Expression of Activin B is required for tumor growth in vivo and tumor cell invasion in vitro. Here we show that activation of RhoA signaling counteracts Activin B mediated disassembly of actin stress fibers, mesenchymal cell morphology and invasiveness, whereas inhibition of RhoA rescues these effects in Activin B knockdown cells. Conversely, Activin B ...[more]