A viral RNA structural element alters host recognition of nonself RNA.
Ontology highlight
ABSTRACT:
SUBMITTER: Hyde JL
PROVIDER: S-EPMC4209899 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Publications
A viral RNA structural element alters host recognition of nonself RNA.
Hyde Jennifer L JL Gardner Christina L CL Kimura Taishi T White James P JP Liu Gai G Trobaugh Derek W DW Huang Cheng C Tonelli Marco M Paessler Slobodan S Takeda Kiyoshi K Klimstra William B WB Amarasinghe Gaya K GK Diamond Michael S MS
Science (New York, N.Y.) 20140130 6172
Although interferon (IFN) signaling induces genes that limit viral infection, many pathogenic viruses overcome this host response. As an example, 2'-O methylation of the 5' cap of viral RNA subverts mammalian antiviral responses by evading restriction of Ifit1, an IFN-stimulated gene that regulates protein synthesis. However, alphaviruses replicate efficiently in cells expressing Ifit1 even though their genomic RNA has a 5' cap lacking 2'-O methylation. We show that pathogenic alphaviruses use s ...[more]
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