Ontology highlight
ABSTRACT:
SUBMITTER: Lin MM
PROVIDER: S-EPMC4210006 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Lin Milo M MM Shorokhov Dmitry D Zewail Ahmed H AH
Proceedings of the National Academy of Sciences of the United States of America 20140922 40
Helices are the "hydrogen atoms" of biomolecular complexity; the DNA/RNA double hairpin and protein α-helix ubiquitously form the building blocks of life's constituents at the nanometer scale. Nevertheless, the formation processes of these structures, especially the dynamical pathways and rates, remain challenging to predict and control. Here, we present a general analytical method for constructing dynamical free-energy landscapes of helices. Such landscapes contain information about the thermod ...[more]