Ontology highlight
ABSTRACT:
SUBMITTER: Jose CC
PROVIDER: S-EPMC4210008 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Jose Cynthia C CC Xu Beisi B Jagannathan Lakshmanan L Trac Candi C Mallela Ramya K RK Hattori Takamitsu T Lai Darson D Koide Shohei S Schones Dustin E DE Cuddapah Suresh S
Proceedings of the National Academy of Sciences of the United States of America 20140922 40
Investigations into the genomic landscape of histone modifications in heterochromatic regions have revealed histone H3 lysine 9 dimethylation (H3K9me2) to be important for differentiation and maintaining cell identity. H3K9me2 is associated with gene silencing and is organized into large repressive domains that exist in close proximity to active genes, indicating the importance of maintenance of proper domain structure. Here we show that nickel, a nonmutagenic environmental carcinogen, disrupted ...[more]