Ontology highlight
ABSTRACT:
SUBMITTER: Longo DL
PROVIDER: S-EPMC4210149 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20141002 41
Chemical exchange saturation transfer (CEST) is a novel contrast mechanism for magnetic resonance imaging (MRI). CEST MRI selectively saturates exchangeable protons that are transferred to MRI-detectable bulk water signal. MRI-CEST (pH)-responsive agents are probes able to map pH in the microenvironment in which they distribute. To minimize the confounding effects of contrast agent concentration, researchers have developed ratiometric CEST imaging, which investigates contrast agents containing m ...[more]