Ontology highlight
ABSTRACT:
SUBMITTER: Gao J
PROVIDER: S-EPMC4210445 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Gao Jie J Schatton Désirée D Martinelli Paola P Hansen Henriette H Pla-Martin David D Barth Esther E Becker Christian C Altmueller Janine J Frommolt Peter P Sardiello Marco M Rugarli Elena I EI
The Journal of cell biology 20141001 2
Mitochondrial function requires coordination of two genomes for protein biogenesis, efficient quality control mechanisms, and appropriate distribution of the organelles within the cell. How these mechanisms are integrated is currently not understood. Loss of the Clu1/CluA homologue (CLUH) gene led to clustering of the mitochondrial network by an unknown mechanism. We find that CLUH is coregulated both with genes encoding mitochondrial proteins and with genes involved in ribosomal biogenesis and ...[more]