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Genome-wide microRNA changes in human intracranial aneurysms.


ABSTRACT: Intracranial aneurysms are pathological dilatations of the cerebral artery, while rupture of intracranial aneurysms causes life-threatening subarachnoid hemorrhage. The molecular mechanisms of pathogenesis of intracranial aneurysms are poorly understood. MicroRNAs have fundamental roles in modulating vascular biology and disease. In the present study, we carried out a genome-wide characterization on expressions of microRNAs, and performed integrative analyses in conjunction with changes of the transcriptome in human intracranial aneurysms.Genome-wide microRNA screening was performed in 6 intracranial aneurysmal samples and 6 normal superficial temporal arteries. Each case and control pair was individually matched with gender, age (±5 years), and high blood pressure history. Microarray analysis was performed using Agilent Human miRNA arrays.As compared to normal arteries, we identified 157 microRNAs that were differentially expressed in the aneurysmal tissue (P?

SUBMITTER: Liu D 

PROVIDER: S-EPMC4210474 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Genome-wide microRNA changes in human intracranial aneurysms.

Liu Dehua D   Han Liang L   Wu Xiao X   Yang Xinjian X   Zhang Qunye Q   Jiang Fan F  

BMC neurology 20141010


<h4>Background</h4>Intracranial aneurysms are pathological dilatations of the cerebral artery, while rupture of intracranial aneurysms causes life-threatening subarachnoid hemorrhage. The molecular mechanisms of pathogenesis of intracranial aneurysms are poorly understood. MicroRNAs have fundamental roles in modulating vascular biology and disease. In the present study, we carried out a genome-wide characterization on expressions of microRNAs, and performed integrative analyses in conjunction wi  ...[more]

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