Ontology highlight
ABSTRACT:
SUBMITTER: Troeberg L
PROVIDER: S-EPMC4210636 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Troeberg Linda L Lazenbatt Christopher C Anower-E-Khuda Md Ferdous MF Freeman Craig C Federov Oleg O Habuchi Hiroko H Habuchi Osami O Kimata Koji K Nagase Hideaki H
Chemistry & biology 20140828 10
Tissue inhibitor of metalloproteinase 3 (TIMP-3) is an important regulator of extracellular matrix (ECM) turnover. TIMP-3 binds to sulfated ECM glycosaminoglycans or is endocytosed by cells via low-density lipoprotein receptor-related protein 1 (LRP-1). Here, we report that heparan sulfate (HS) and chondroitin sulfate E (CSE) selectively regulate postsecretory trafficking of TIMP-3 by inhibiting its binding to LRP-1. HS and CSE also increased TIMP-3 affinity for glycan-binding metalloproteinases ...[more]