OGA inhibition by GlcNAc-selenazoline.
Ontology highlight
ABSTRACT:
SUBMITTER: Kim EJ
PROVIDER: S-EPMC4210863 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Publications
OGA inhibition by GlcNAc-selenazoline.
Kim Eun Ju EJ Love Dona C DC Darout Etzer E Abdo Mohannad M Rempel Brian B Withers Stephen G SG Rablen Paul R PR Hanover John A JA Knapp Spencer S
Bioorganic & medicinal chemistry 20100811 19
The title compound, which differs from the powerful O-GlcNAcase (OGA) inhibitor GlcNAc-thiazoline only at the chalcogen atom (Se for S), is a much weaker inhibitor in a direct OGA assay. In human cells, however, the selenazoline shows comparable ability to induce hyper-O-GlcNAc-ylation, and the two show similar reduction of insulin-stimulated translocation of glucose transporter 4 in differentiated 3T3 adipocytes. ...[more]
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