OGA inhibition by GlcNAc-selenazoline.

ABSTRACT: The title compound, which differs from the powerful O-GlcNAcase (OGA) inhibitor GlcNAc-thiazoline only at the chalcogen atom (Se for S), is a much weaker inhibitor in a direct OGA assay. In human cells, however, the selenazoline shows comparable ability to induce hyper-O-GlcNAc-ylation, and the two show similar reduction of insulin-stimulated translocation of glucose transporter 4 in differentiated 3T3 adipocytes.

SUBMITTER: Kim EJ 

PROVIDER: S-EPMC4210863 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature