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Exposure to endocrine disrupters and nuclear receptor gene expression in infertile and fertile women from different Italian areas.


ABSTRACT: Within the PREVIENI project, infertile and fertile women were enrolled from metropolitan, urban and rural Italian areas. Blood/serum levels of several endocrine disrupters (EDs) (perfluorooctane sulfonate, PFOS; perfluorooctanoic acid, PFOA; di-2-ethylhexyl-phthalate, DEHP; mono-(2-ethylhexyl)-phthalate, MEHP; bisphenol A, BPA) were evaluated concurrently with nuclear receptors (NRs) gene expression levels (ERa, ERb, AR, AhR, PPARg, PXR) in peripheral blood mononuclear cells (PBMCs). Infertile women from the metropolitan area displayed significantly higher levels of: BPA compared to fertile women (14.9 vs. 0.5 ng/mL serum); BPA and MEHP compared to infertile women from urban and rural areas; enhanced expression levels of NRs, except PPARg. Infertile women from urban and rural areas had PFOA levels significantly higher than those from metropolitan areas. Our study indicates the relevance of the living environment when investigating the exposure to EDs and the modulation of the NR panel in PBMC as a suitable biomarker of the effect, to assess the EDs impact on reproductive health.

SUBMITTER: La Rocca C 

PROVIDER: S-EPMC4210972 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Exposure to endocrine disrupters and nuclear receptor gene expression in infertile and fertile women from different Italian areas.

La Rocca Cinzia C   Tait Sabrina S   Guerranti Cristiana C   Busani Luca L   Ciardo Francesca F   Bergamasco Bruno B   Stecca Laura L   Perra Guido G   Mancini Francesca Romana FR   Marci Roberto R   Bordi Giulia G   Caserta Donatella D   Focardi Silvano S   Moscarini Massimo M   Mantovani Alberto A  

International journal of environmental research and public health 20140929 10


Within the PREVIENI project, infertile and fertile women were enrolled from metropolitan, urban and rural Italian areas. Blood/serum levels of several endocrine disrupters (EDs) (perfluorooctane sulfonate, PFOS; perfluorooctanoic acid, PFOA; di-2-ethylhexyl-phthalate, DEHP; mono-(2-ethylhexyl)-phthalate, MEHP; bisphenol A, BPA) were evaluated concurrently with nuclear receptors (NRs) gene expression levels (ERa, ERb, AR, AhR, PPARg, PXR) in peripheral blood mononuclear cells (PBMCs). Infertile w  ...[more]

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