Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC4211265 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Chen X X Hickling T P TP Vicini P P
CPT: pharmacometrics & systems pharmacology 20140903
A mechanistic, multiscale mathematical model of immunogenicity for therapeutic proteins was formulated by recapitulating key biological mechanisms, including antigen presentation, activation, proliferation, and differentiation of immune cells, secretion of antidrug antibodies (ADA), as well as in vivo disposition of ADA and therapeutic proteins. This system-level model contains three scales: a subcellular level representing antigen presentation processes by dendritic cells; a cellular level acco ...[more]