Ontology highlight
ABSTRACT:
SUBMITTER: Abu-Remaileh M
PROVIDER: S-EPMC4211377 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Abu-Remaileh M M Aqeilan R I RI
Cell death and differentiation 20140711 11
The WW domain-containing oxidoreductase (WWOX) encodes a tumor suppressor that is frequently lost in many cancer types. Wwox-deficient mice develop normally but succumb to a lethal hypoglycemia early in life. Here, we identify WWOX as a tumor suppressor with emerging role in regulation of aerobic glycolysis. WWOX controls glycolytic genes' expression through hypoxia-inducible transcription factor 1α (HIF1α) regulation. Specifically, WWOX, via its first WW domain, physically interacts with HIF1α ...[more]