The path of least resistance: aggressive or moderate treatment?
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ABSTRACT:
SUBMITTER: Kouyos RD
PROVIDER: S-EPMC4211439 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
The path of least resistance: aggressive or moderate treatment?
Kouyos Roger D RD Metcalf C Jessica E CJ Birger Ruthie R Klein Eili Y EY Abel zur Wiesch Pia P Ankomah Peter P Arinaminpathy Nimalan N Bogich Tiffany L TL Bonhoeffer Sebastian S Brower Charles C Chi-Johnston Geoffrey G Cohen Ted T Day Troy T Greenhouse Bryan B Huijben Silvie S Metlay Joshua J Mideo Nicole N Pollitt Laura C LC Read Andrew F AF Smith David L DL Standley Claire C Wale Nina N Grenfell Bryan B
Proceedings. Biological sciences 20141101 1794
The evolution of resistance to antimicrobial chemotherapy is a major and growing cause of human mortality and morbidity. Comparatively little attention has been paid to how different patient treatment strategies shape the evolution of resistance. In particular, it is not clear whether treating individual patients aggressively with high drug dosages and long treatment durations, or moderately with low dosages and short durations can better prevent the evolution and spread of drug resistance. Here ...[more]
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