Alpha-ethyltryptamines as dual dopamine-serotonin releasers.
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ABSTRACT:
SUBMITTER: Blough BE
PROVIDER: S-EPMC4211607 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Alpha-ethyltryptamines as dual dopamine-serotonin releasers.
Blough Bruce E BE Landavazo Antonio A Partilla John S JS Decker Ann M AM Page Kevin M KM Baumann Michael H MH Rothman Richard B RB
Bioorganic & medicinal chemistry letters 20140729 19
The dopamine (DA), serotonin (5-HT), and norepinephrine (NE) transporter releasing activity and serotonin-2A (5-HT2A) receptor agonist activity of a series of substituted tryptamines are reported. Three compounds, 7b, (+)-7d and 7f, were found to be potent dual DA/5-HT releasers and were >10-fold less potent as NE releasers. Additionally, these compounds had different activity profiles at the 5-HT2A receptor. The unique combination of dual DA/5-HT releasing activity and 5-HT2A receptor activity ...[more]
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