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Puberty and the manifestations of loss of control eating in children and adolescents.

ABSTRACT: OBJECTIVE:We investigated the manifestations of pediatric loss of control (LOC) eating at different stages of pubertal development. METHOD:Participants were a nonclinical sample of 468 youth (8-17 years). Physical examination determined pubertal stage. LOC eating and disordered eating attitudes were assessed with the Eating Disorder Examination. In a randomized crossover design, a subset (n?=?244) ate ad libitum from two test meals designed to capture normal and LOC eating. RESULTS:There were no differences in the prevalence rates or frequency of reported LOC eating episodes across pubertal stages (ps???0.50). There were, however, puberty by LOC eating interactions in disordered eating attitudes and palatable food consumption (ps???.05), even after adjusting for age and body composition. LOC eating was associated with elevated global disordered eating attitudes, weight concern, and shape concern in post-pubertal youth (ps ? .001), but not pre-pubertal youth (ps???.49). In late-puberty, youth with LOC eating consumed less energy from protein (p?

SUBMITTER: Vannucci A

PROVIDER: S-EPMC4211942 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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Puberty and the manifestations of loss of control eating in children and adolescents.

Vannucci Anna A Tanofsky-Kraff Marian M Ranzenhofer Lisa M LM Kelly Nichole R NR Hannallah Louise M LM Pickworth C Katie CK Grygorenko Mariya V MV Brady Sheila M SM Condarco Tania A TA Kozlosky Merel M Demidowich Andrew P AP Yanovski Susan Z SZ Shomaker Lauren B LB Yanovski Jack A JA

The International journal of eating disorders 20140530 7

<h4>Objective</h4>We investigated the manifestations of pediatric loss of control (LOC) eating at different stages of pubertal development.<h4>Method</h4>Participants were a nonclinical sample of 468 youth (8-17 years). Physical examination determined pubertal stage. LOC eating and disordered eating attitudes were assessed with the Eating Disorder Examination. In a randomized crossover design, a subset (n = 244) ate ad libitum from two test meals designed to capture normal and LOC eating.<h4>Res ...[more]

PMID: 24888295

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Project description:BACKGROUND:Arrhythmogenic cardiomyopathy (ACM) is a variably penetrant disease increasingly identified in young patients. OBJECTIVES:This study sought to describe the diverse phenotype, genotype, and outcomes in pediatric and adolescent patients. METHODS:Records from 1999 to 2016 were reviewed for individuals age <21 years with a consistent personal or family history. Patients were categorized by right ventricular (RV), left dominant (LD), or biventricular subtypes using 2010 Task Force Criteria or proposed features of LD disease, encompassing electrocardiographic, structural, histological, and arrhythmic characteristics. Genetic variants classified as pathogenic and/or likely pathogenic by 2015 American College of Medical Genetics and Genomics criteria in recognized disease-associated genes were included. RESULTS:Manifest disease was evident in 32 patients (age 15.1 ± 3.8 years), of whom 22 were probands, including 16 RV, 7 LD, and 9 biventricular ACM. Nondiagnostic features were seen in 5 of 15 family members. RV disease was associated with cardiac arrest and ventricular tachycardia (p = 0.02) and prevalence of PKP2 variants (p < 0.01), whereas biventricular disease was associated with a younger age of onset (p = 0.02). LD ACM was associated with variants in DSP and LMNA, and biventricular ACM with more a diverse etiology in desmosomal genes. Cardiac arrest was observed in 5 probands (age 15.3 ± 1.9 years) and ventricular tachycardia in 10 (age 16.6 ± 2.7 years), 6 probands, and 4 family members. Features suggestive of myocardial inflammation were seen in 6 patients, with ventricular tachycardia and/or cardiac arrest in 3 patients. Cardiac transplantation was performed in 10 patients. There were no deaths. In RV and biventricular disease, electrocardiographic preceded imaging features, whereas the reverse was seen in LD disease. CONCLUSIONS:ACM in the young has highly varied phenotypic expression incorporating life-threatening arrhythmia, heart failure, and myocardial inflammation. Increased awareness of early onset, aggressive disease has important implications for patient management and familial screening.

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Puberty and the manifestations of loss of control eating in children and adolescents.

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Puberty and the manifestations of loss of control eating in children and adolescents.

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