Unknown

Dataset Information

0

Fat-soluble vitamins in cystic fibrosis and pancreatic insufficiency: efficacy of a nutrition intervention.


ABSTRACT: OBJECTIVES:The aim of the study was to assess the impact of LYM-X-SORB (LXS), an organized lipid matrix that has been shown to be absorbable without pancreatic enzyme therapy on fat-soluble vitamin status in children with cystic fibrosis (CF) and pancreatic insufficiency (PI). METHODS:Children with CF and PI were randomized to daily LXS or an isocaloric placebo comparison supplement for 12 months. Serum vitamins A (retinol), D (25-hydroxyvitamin D[25D]), E (?-tocopherol, ?-tocopherol:cholesterol ratio), and K (percentage of undercarboxylated osteocalcin [%ucOC] and plasma proteins induced by vitamin K absence factor II [PIVKA II]) were assessed at baseline and 12 months. Dietary intake was determined using 3-day weighed food records and supplemental vitamin intake by a comprehensive questionnaire. RESULTS:A total of 58 subjects (32 boys, age 10.3 ± 2.9 years [mean ± standard deviation]) with complete serum vitamin, dietary and supplemental vitamin data were analyzed. After adjusting for dietary and supplemental vitamin intake, serum retinol increased 3.0 ± 1.4 ?g/dL (coefficient ± standard error) (adjusted R2 = 0.02, P = 0.03) and vitamin K status improved as demonstrated by a decreased percentage of undercarboxylated osteocalcin of -6.0% ± 1.6% by 12 months (adjusted R2 = 0.15, P < 0.001). These changes occurred in both the LXS and placebo comparison groups. No changes in serum 25D or ?-tocopherol were detected. Both nutrition interventions increased caloric intake a mean of 83 ± 666 kcal/day by 12 months. CONCLUSIONS:Vitamins A and K status improved, whereas vitamins D and E status was unchanged during 12 months of LXS and isocaloric placebo comparison supplement in children with CF and PI.

SUBMITTER: Bertolaso C 

PROVIDER: S-EPMC4212898 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Fat-soluble vitamins in cystic fibrosis and pancreatic insufficiency: efficacy of a nutrition intervention.

Bertolaso Chiara C   Groleau Veronique V   Schall Joan I JI   Maqbool Asim A   Mascarenhas Maria M   Latham Norma E NE   Dougherty Kelly A KA   Stallings Virginia A VA  

Journal of pediatric gastroenterology and nutrition 20140401 4


<h4>Objectives</h4>The aim of the study was to assess the impact of LYM-X-SORB (LXS), an organized lipid matrix that has been shown to be absorbable without pancreatic enzyme therapy on fat-soluble vitamin status in children with cystic fibrosis (CF) and pancreatic insufficiency (PI).<h4>Methods</h4>Children with CF and PI were randomized to daily LXS or an isocaloric placebo comparison supplement for 12 months. Serum vitamins A (retinol), D (25-hydroxyvitamin D[25D]), E (α-tocopherol, α-tocophe  ...[more]

Similar Datasets

| S-EPMC4214079 | biostudies-literature
| S-EPMC1727456 | biostudies-other
| S-EPMC2621407 | biostudies-other
| S-EPMC3529461 | biostudies-literature
| S-EPMC10255381 | biostudies-literature
| S-EPMC2863217 | biostudies-literature
| S-EPMC3067733 | biostudies-literature
| S-EPMC11301217 | biostudies-literature
| S-EPMC4841899 | biostudies-literature
| S-EPMC2690417 | biostudies-literature