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A generator-produced gallium-68 radiopharmaceutical for PET imaging of myocardial perfusion.


ABSTRACT: Lipophilic cationic technetium-99m-complexes are widely used for myocardial perfusion imaging (MPI). However, inherent uncertainties in the supply chain of molybdenum-99, the parent isotope required for manufacturing 99Mo/99mTc generators, intensifies the need for discovery of novel MPI agents incorporating alternative radionuclides. Recently, germanium/gallium (Ge/Ga) generators capable of producing high quality 68Ga, an isotope with excellent emission characteristics for clinical PET imaging, have emerged. Herein, we report a novel 68Ga-complex identified through mechanism-based cell screening that holds promise as a generator-produced radiopharmaceutical for PET MPI.

SUBMITTER: Sharma V 

PROVIDER: S-EPMC4212944 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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A generator-produced gallium-68 radiopharmaceutical for PET imaging of myocardial perfusion.

Sharma Vijay V   Sivapackiam Jothilingam J   Harpstrite Scott E SE   Prior Julie L JL   Gu Hannah H   Rath Nigam P NP   Piwnica-Worms David D  

PloS one 20141029 10


Lipophilic cationic technetium-99m-complexes are widely used for myocardial perfusion imaging (MPI). However, inherent uncertainties in the supply chain of molybdenum-99, the parent isotope required for manufacturing 99Mo/99mTc generators, intensifies the need for discovery of novel MPI agents incorporating alternative radionuclides. Recently, germanium/gallium (Ge/Ga) generators capable of producing high quality 68Ga, an isotope with excellent emission characteristics for clinical PET imaging,  ...[more]

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