An ESR and DFT study of hydration of the 2'-deoxyuridine-5-yl radical: a possible hydroxyl radical intermediate.
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ABSTRACT:
SUBMITTER: Chomicz L
PROVIDER: S-EPMC4213299 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
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An ESR and DFT study of hydration of the 2'-deoxyuridine-5-yl radical: a possible hydroxyl radical intermediate.
Chomicz Lidia L Petrovici Alex A Archbold Ian I Adhikary Amitava A Kumar Anil A Sevilla Michael D MD Rak Janusz J
Chemical communications (Cambridge, England) 20141201 93
The mechanism of radiation-induced frank strand break formation in irradiated 5-bromo-2'-deoxyuridine (BrdU)-labelled DNA is still unclear despite the proven radiosensitizing properties of BrdU. Combination of ESR spectroscopy and quantum chemical modelling points to a simple reaction between the uridine-5-yl radical and water molecules that produces the genotoxic hydroxyl radical. ...[more]
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