Current perspectives on HIV-1 antiretroviral drug resistance.
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ABSTRACT:
SUBMITTER: Iyidogan P
PROVIDER: S-EPMC4213579 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Current perspectives on HIV-1 antiretroviral drug resistance.
Iyidogan Pinar P Anderson Karen S KS
Viruses 20141024 10
Current advancements in antiretroviral therapy (ART) have turned HIV-1 infection into a chronic and manageable disease. However, treatment is only effective until HIV-1 develops resistance against the administered drugs. The most recent antiretroviral drugs have become superior at delaying the evolution of acquired drug resistance. In this review, the viral fitness and its correlation to HIV-1 mutation rates and drug resistance are discussed while emphasizing the concept of lethal mutagenesis as ...[more]
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